2020-12-18

Rai, Ratan K.

Nuclear magnet resonance (NMR) is a powerful technique to detect and characterize the 3D structures, dynamics, and interactions of biomacromolecules. With respect to drug targets, this methodology provides an excellent tool for the identification of small organic molecules that bind weakly to a target macromolecule as fragments of candidate inhibitors. In this presentation, Ratan K. Rai, PhD (Assistant Research Professor of Biochemistry and Molecular Biology, Indiana University School of Medicine) explains the principles of NMR and its application as a tool for fragment-based drug discovery. Strategies to utilize this approach are described to identify and validate initial hits. The Chemical Genomics Core Facility is equipped with a 600 MHz solution NMR with cryo-probe for the structure elucidation of biomolecules and studies of ligand interactions.

Indiana University School of Medicine; Indiana Clinical and Translational Sciences Institute

Ruth Lilly Medical Library

Educational

Drugs Design; Drugs Structure-Activity Relationships; Nuclear Magnetic Resonance; Pharmacology

Cutting-Edge Drug Discovery Tools at the Chemical Genomics Core Facility

Ruth Lilly Medical Library